For the Treatment of ALK+ mNSCLC
Choose ALUNBRIG® (brigatinib) for First-Line Efficacy and Long-Term Tolerability1,2,a

Lungs made up of hobbies and images of power. First-line power. Real-life passions. Don't compromise.

aLong-term tolerability is based on the median follow-up in the ALUNBRIG arm of ALTA 1L: 40.4 months.2

Category 1, preferred NCCN recommendation. Brigatinib (ALUNBRIG) is an FDA-approved TKI, recommended by the National Comprehensive Cancer Network® (NCCN®) as a Category 1 preferred first-¬line treatment option for ALK+ advanced or metastatic NSCLC.

Systemic
Efficacy

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Watch Dr. Taha share ALUNBRIG systemic efficacy data.

Intracranial 
Activity

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Watch Dr. Taha share ALUNBRIG intracranial activity and outcomes.

Safety and Tolerability

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Watch advanced practitioner Sarah Karpen share key safety data and management tips.

Getting started with ALUNBRIG

Learn more about getting started on treatment.

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Sarah: 
When patients are first diagnosed with ALK positive, non-small cell lung cancer, they usually feel like the floor just dropped out beneath them, and they don't know what is going to happen next. 

 

Summer: 
I received my ALK positive lung cancer diagnosis in the summer of 2020, and I went from being a caregiver to my 19-year-old son with cerebral palsy to a patient in the blink of an eye, it was answers to months of debilitating shortness of breath and coughing, but it was also a devastating blow to myself and to my family.

Once I received the ALK positive diagnosis, I dove in headfirst and trying, tried to absorb and obtain all information I could get my hands on. I first went to the ALK positive website. From there, I found an ALK positive support group so I could read articles and also hear from other patients living with the disease. 

 

Dr. Vivek: 
ALK positive metastatic non-small cell lung cancer patients are very unique. It is a rare it's a very rare subset of non-small cell lung cancer.

Treatment for metastatic, non-small cell lung cancer, ALK positive patients can be quite diverse. I like to be involved with the shared decision making, where I tell the patient and the family what different treatment approaches that we have for this type of lung cancer, all the different medications, I like to talk to them about, the side effects, take into account their comorbidities, and then, together with the patient and the family, we come to a conclusion of what is the best treatment for them. 

 

Sarah:
When I present ALUNBRIG to my patients, the number one thing that I tell them first is, this is a pill, and most patients are excited about the option to take a once daily pill.

 

Summer: 
My oncologist and nurse practitioner laid the initial groundwork for getting started on ALUNBRIG, but then I also had a phone call with a specialty pharmacist.

 

Sarah: 
When patients begin ALUNBRIG. It's important to make sure that we monitor them very closely, especially in the beginning of their treatment process. So, 48 hours after starting this medication, we will have a visit with the patient. We'll check their blood pressure, and then we see them one week later. We'll continue seeing them on a weekly cadence for the first month after starting their medication. As long as everything is stable, their labs are normal, and their vital signs are also normal. We can move that to about one month.

In my experience, ALUNBRIG has afforded me to be so close to my baseline with minimal side effects. Of course, my labs have to be monitored and scans, but that's with any treatment option. 

 

Sarah: 
For healthcare providers considering ALUNBRIG, I think the top thing to mention is the ease of dosing. This medication can be given once daily, and it's one pill. The second thing, I think, is very important also to mention is the ramp up dosing that this pill has for patients starting this treatment, they take 90 milligrams for the first seven days, and then 180 milligrams moving forward. This also helps patients stay on treatment.

 

Summer:
For patients considering ALUNBRIG, please remember going with eyes wide open ALUNBRIG is such a great treatment option when we have so many different options in the ALK positive landscape. 

Connect With Our Team

Learn more about first-line ALUNBRIG for patients with ALK+ mNSCLC from an ALUNBRIG representative. 

bWhen an ALK gene fusion is discovered prior to first-line systemic therapy.
cThe NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for NSCLC provide recommendations for individual biomarkers that should be tested and recommend testing techniques, but do not endorse any specific commercially available biomarker assays or commercial laboratories.
dSee the NCCN Guidelines® for detailed recommendations, including other preferred treatment options.

ALK, anaplastic lymphoma kinase; ALK+, ALK-positive; FDA, US Food and Drug Administration; mNSCLC, metastatic NSCLC; NCCN, National Comprehensive Cancer Network® (NCCN®); NSCLC, non-small cell lung cancer; TKI, tyrosine kinase inhibitor.