ALUNBRIG® (brigatinib) is indicated for the treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) as detected by an FDA-approved test.

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to identify patients eligible

Exploring Key Safety and Patient Data

Dr. Alex Spira, Director of the Virginia Cancer Specialists Research Institute, discusses ALUNBRIG for the treatment of adult patients with ALK+ mNSCLC.

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FoundationOne®CDx is a qualitative, next-generation sequencing–based, in vitro, diagnostic test for advanced cancer patients with solid tumors and is for prescription use only. The test analyzes 324 genes as well as genomic signatures, including microsatellite instability (MSI) and tumor mutational burden (TMB), and is a companion diagnostic to identify patients who may benefit from treatment with specific therapies in accordance with the approved therapeutic product labeling. Additional genomic findings may be reported and are not prescriptive or conclusive for labeled use of any specific therapeutic product. Use of the test does not guarantee a patient will be matched to a treatment. A negative result does not rule out the presence of an alteration. Some patients may require a biopsy. For the complete label, including companion diagnostic indications and important risk information, please visit


1. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Non-Small Cell Lung Cancer v.6 2021. © National Comprehensive Cancer Network, Inc. 2021. All rights reserved. Accessed October 28, 2021. To view the most recent and complete version of the guideline, go online to NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way. 2. FoundationOne CDx summary of safety and efficacy, Foundation Medicine, Inc; 2021. Accessed July 1, 2021.

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In Vitro: ALUNBRIG Inhibited 17
ALK-Inhibitor—Resistant Mutations1,2

ALUNBRIG exhibited in vivo antitumor activity against 4 mutant forms of EML4-ALK, including the G1202R and L1196M mutants identified in NSCLC tumors in patients who had progressed on crizotinib.


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