Learn About Treatment With ALUNBRIG^® (brigatinib) for ALK+ Metastatic Non-Small Cell Lung Cancer (mNSCLC)

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Eric & Meghan's Story

Learn about how Eric and Meghan have navigated Eric’s ALK+ mNSCLC diagnosis, their experience with ALUNBRIG, and how together they are living with lung cancer.

Eric is a real ALUNBRIG patient

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[Meghan]
Eric and I have been married for about 10 years, we have a pretty vibrant life.
A lung cancer diagnosis made no sense to us.
Often people say it's like having the rug pulled out from underneath you, when you get a diagnosis like that. I correct them. And I say it's like the whole floor, coming out from underneath you.
When we got that phone call or news from the physician of his cancer diagnosis, I knew it would be a major inflection point in our life.

[Eric]
Prior to diagnosis, my health started to change in such a way that I was having difficulty breathing. And I was coughing quite a bit.
The symptoms that I had, definitely felt like someone standing on my chest. I was also having difficulty sleeping on my back, which led me to a lot more sleepless nights.
It came up in a conversation with my wife and after she said, “Hey, I'm concerned that your coughing is becoming uncontrollable. I think it's time for you to visit your primary care physician.”
It was a very short period of time, I was able to go from an x-ray to a CT in the same day. And then within two days, I was doing a biopsy.
The first time that I heard the word cancer, from my physician. I will never forget those words.
At age 41. I was diagnosed with stage four ALK positive non-small cell lung cancer. Receiving a diagnosis of this sort, made no sense to me.

[Meghan]
We've obviously subsequently learned that anyone with lungs can get lung cancer.

[Eric]
It took me a while to understand the impact of having brain metastases. And at that point, I was honestly so defeated and downtrodden.
As my treatment options were explained to me, I had the choice of a few different TKIs. I consulted with my family, my oncologists and other primary care specialists to pick the best option for me based on the side effects and the dosing. And for me, that choice was ALUNBRIG.
ALUNBRIG is a prescription medicine used to treat adults with non-small cell lung cancer, NSCLC, that has a certain type of abnormal anaplastic lymphoma kinase, ALK, gene and that has spread to other parts of your body. It is not known if ALUNBRIG is safe and effective in children.
The most important factor when selecting ALUNBRIG was how it would impact my life. And I looked at the side effects and the dosage. And those two combined, made it feel that it would be the least impactful to my everyday life.
I've experienced bradycardia nausea and stomach pain while taking ALUNBRIG. But these are not all of the possible side effects. And everyone is different.
Speak to your healthcare provider about all the potential side effects with ALUNBRIG.

[Meghan]
The treatment was very easy to incorporate into our lives. Being able to take one pill a day was of a significant benefit to him as well.

[Eric]
I started ALUNBRIG on the seven-day starter dosage of 90 milligrams, after which I increased to 180 milligrams, which I currently take.

[Meghan]
From my perspective, Eric has responded really well to ALUNBRIG.
Fortunately, it had a rapid reduction in his tumor volume. He was able to tolerate the medicine.

[Eric]
After reading my scan reports, one of the terms frequently used is “unremarkable”. That effectively means that while my tumors are still present, they're not growing or spreading. So, I will happily claim to be an “unremarkable cancer patient”.

[Meghan]
When Eric was first diagnosed with lung cancer, he was given a prognosis of nine to 12 months. That timing then aligned with our 10-year wedding anniversary. So, our goal became to make it to the anniversary.
And as we did, we elected to have a vow renewal ceremony with a number of family and friends.
We're able to take less of the focus on his treatment and the worry and put it more so into creating memories together.

[Eric]
The best piece of advice that I've received from my care is that you don't have to hit a homerun your first at bat. You have to get on base. You have to stay healthy enough to take advantage of technology and its advances.
And that's what gives me hope.

IMPORTANT SAFETY INFORMATION

ALUNBRIG can cause serious side effects, including:

Lung problems. ALUNBRIG may cause severe or life-threatening swelling (inflammation) of the lungs any time during treatment and can lead to death. These lung problems happen especially within the first week of treatment with ALUNBRIG. Symptoms may be similar to those symptoms from lung cancer. Tell your healthcare provider right away if you have any new or worsening symptoms. including:

trouble breathing or shortness of breath
chest pain
cough with or without mucus
fever

High blood pressure (hypertension). ALUNBRIG may cause high blood pressure. Your healthcare provider will check your blood pressure before starting and during treatment with ALUNBRIG. Tell your healthcare provider right away if you get headaches, dizziness, blurred vision, chest pain or shortness of breath.

Slow heart rate (bradycardia). ALUNBRIG may cause very slow heartbeats that can be severe. Your healthcare provider will check your heart rate during treatment with ALUNBRIG. Tell your healthcare provider right away if you feel dizzy, lightheaded, or faint during treatment with ALUNBRIG. Tell your healthcare provider if you take any heart or blood pressure medicines.

Vision problems. ALUNBRIG may cause vision problems. Your healthcare provider may stop ALUNBRIG and refer you to an eye specialist if you develop severe vision problems during treatment with ALUNBRIG. Tell your healthcare provider right away if you have any loss of vision or any change in vision, including:

double vision
seeing flashes of light
blurry vision
light hurting your eyes
new or increased floaters

Muscle pain, tenderness, and weakness (myalgia). ALUNBRIG may increase the level of an enzyme in your blood called creatine phosphokinase (CPK), which may be a sign of muscle damage. Your healthcare provider will do blood tests to check your blood levels of CPK during treatment with ALUNBRIG. Tell your healthcare provider right away if you get new or worsening signs and symptoms of muscle problems, including unexplained muscle pain or muscle pain that does not go away, tenderness, or weakness.

Inflammation of the pancreas (pancreatitis). ALUNBRIG may increase enzymes in your blood called amylase and lipase, which may be a sign of pancreatitis. Your healthcare provider will do blood tests to check your pancreatic enzyme blood levels during treatment with ALUNBRIG. Tell your healthcare provider right away if you get new or worsening signs and symptoms of pancreatitis, including upper abdominal pain that may spread to the back and get worse with eating, weight loss, or nausea.

Liver problems (hepatotoxicity). ALUNBRIG may increase the levels of bilirubin in your blood and enzymes called aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in your blood, which may be a sign of liver problems. Your healthcare provider will do blood tests to check your liver during treatment with ALUNBRIG. Tell your healthcare provider right away if you get new or worsening signs or symptoms, including:

yellowing of your skin or the white part of your eyes
dark or brown (tea color) urine
nausea or vomiting
pain on the right side of your stomach area
bleed or bruise more easily than normal
itchy skin
decreased appetite
feeling tired

High blood sugar (hyperglycemia). ALUNBRIG may increase your blood sugar levels. Your healthcare provider will do blood tests to check your blood sugar levels before starting and during treatment with ALUNBRIG. Your healthcare provider may need to start or change your blood sugar medicine to control your blood sugar levels. Tell your healthcare provider right away if you get new or worsening signs and symptoms of hyperglycemia, including:

feeling very thirsty
needing to urinate more than usual
feeling very hungry
feeling sick to your stomach
feeling weak or tired
feeling confused

The most common side effects of ALUNBRIG include diarrhea, fatigue, nausea, rash, cough, muscle pain, headache, high blood pressure, vomiting and difficulty breathing.

ALUNBRIG may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of ALUNBRIG. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

What should I avoid while taking ALUNBRIG?

Limit your time in the sun during treatment with ALUNBRIG and for at least 5 days after your final dose. ALUNBRIG may make your skin sensitive to sunlight. You may burn more easily and get severe sunburns. When you are in the sun, wear a hat and protective clothing, and use a broad-spectrum sunscreen and lip balm with a Sun Protection Factor (SPF) of 30 or greater to protect against sunburn.

Avoid eating grapefruit or drinking grapefruit juice during treatment with ALUNBRIG. Grapefruit may increase the amount of ALUNBRIG in your blood.

Before you take ALUNBRIG, tell your healthcare provider about all of your medical conditions, including if you have lung or breathing problems, high blood pressure, a slow heartbeat, or any vision problems, have or have had pancreatitis, have liver problems, have diabetes mellitus or glucose intolerance, have kidney problems or are on dialysis, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

ALUNBRIG can harm your unborn baby. Your healthcare provider will determine whether or not you are pregnant before you start treatment with ALUNBRIG. Tell your healthcare provider right away if you become pregnant during treatment with ALUNBRIG or think you may be pregnant.

Females who are able to become pregnant should use effective birth control during treatment with ALUNBRIG and for at least 4 months after the final dose of ALUNBRIG. Talk to your healthcare provider about birth control choices that are right for you during treatment with ALUNBRIG.
Males who have female partners who are able to become pregnant should use effective birth control during treatment with ALUNBRIG and for at least 3 months after the final dose of ALUNBRIG.

It is not known if ALUNBRIG passes into your breast milk. Do not breastfeed during treatment with ALUNBRIG and for 1 week after the final dose of ALUNBRIG.

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, or herbal supplements.

Learn About Treatment With ALUNBRIG^® (brigatinib) for ALK+ Metastatic Non-Small Cell Lung Cancer (mNSCLC)

If You Are Newly Diagnosed

After Treatment With Crizotinib

Important Resources for You

Eric & Meghan's Story

IMPORTANT SAFETY INFORMATION, INDICATION, AND USAGE

ALUNBRIG can cause serious side effects, including:

What should I avoid while taking ALUNBRIG?

What is ALUNBRIG?