What Is the Most Important Information I Should Know About ALUNBRIG® (brigatinib)

ALUNBRIG can cause serious side effects. Side effects can vary from person to person. As always, communicate with your healthcare provider and be open to asking any questions you have.
 

ALUNBRIG® Can Cause Serious Side Effects, Including:

Lung problems

  • ALUNBRIG may cause severe or life-threatening swelling (inflammation) of the lungs any time during treatment, and can lead to death. These lung problems happen especially within the first week of treatment with ALUNBRIG. Symptoms may be similar to those symptoms from lung cancer. Tell your healthcare provider right away if you have any new or worsening symptoms, including:
    • trouble breathing or shortness of breath
    • chest pain
    • cough with or without mucus
    • fever

High blood pressure (hypertension)

  • ALUNBRIG may cause high blood pressure. Your healthcare provider will check your blood pressure before starting and during treatment with ALUNBRIG. Tell your healthcare provider right away if you get headaches, dizziness, blurred vision, chest pain or shortness of breath

Slow heart rate (bradycardia)

  • ALUNBRIG may cause very slow heartbeats that can be severe. Your healthcare provider will check your heart rate during treatment with ALUNBRIG. Tell your healthcare provider right away if you feel dizzy, lightheaded, or faint during treatment with ALUNBRIG. Tell your healthcare provider if you start to take or have any changes in heart or blood pressure medicines.

Vision problems

  • ALUNBRIG may cause vision problems. Your healthcare provider may stop ALUNBRIG and refer you to an eye doctor if you develop severe vision problems during treatment with ALUNBRIG. Tell your healthcare provider right away if you have any loss of vision or any change in vision, including:
    • double vision
    • seeing flashes of light
    • blurry vision
    • light hurting your eyes
    • new or increased floaters

Muscle pain, tenderness, and weakness (myalgia)

  • ALUNBRIG may increase the level of an enzyme in your blood called creatine phosphokinase (CPK), which may be a sign of muscle damage. Your healthcare provider will do blood tests to check your blood levels of CPK during treatment with ALUNBRIG. Tell your healthcare provider right away if you get new or worsening signs and symptoms of muscle problems, including unexplained muscle pain or muscle pain that does not go away, tenderness, or weakness

Inflammation of the pancreas (pancreatitis)

  • ALUNBRIG may increase enzymes in your blood called amylase and lipase, which may be a sign of pancreatitis. Your healthcare provider will do blood tests to check your pancreatic enzyme blood levels during treatment with ALUNBRIG. Tell your healthcare provider right away if you get new or worsening signs and symptoms of pancreatitis, including upper abdominal pain that may spread to the back and get worse with eating, weight loss, or nausea

High blood sugar (hyperglycemia)

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with ALUNBRIG if you have certain side effects.
  • ALUNBRIG may increase your blood sugar levels. Your healthcare provider will do blood tests to check your blood sugar levels before starting and during treatment with ALUNBRIG. Your healthcare provider may need to start or change your blood sugar medicine to control your blood sugar levels. Tell your healthcare provider right away if you get new or worsening signs and symptoms of hyperglycemia, including:
    • feeling very thirsty
    • needing to urinate more than usual
    • feeling very hungry
    • feeling sick to your stomach
    • feeling weak or tired
    • feeling confused
Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with ALUNBRIG if you have certain side effects.
It’s normal to have questions as you begin your treatment on ALUNBRIG®. We have additional resources for you to discuss with your healthcare provider as you get started. Learn More

Common Side Effects

The most common side effects of ALUNBRIG include:

  • nausea
  • diarrhea
  • fatigue
  • cough
  • headache

ALUNBRIG may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of ALUNBRIG. For more information, ask your healthcare provider or pharmacist. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Speak with your healthcare provider about any side effects you may experience.
Take notes on how you are feeling and share them with your healthcare provider.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch.
You may also report side effects directly to Takeda Oncology at
1-844-A1POINT (1-844-217-6468) or
GlobalOncologyMedinfo@Takeda.com.

ALUNBRIG(TM) BRIGATINIB 39 mg TABLETS

This site is intended for residents
of the US and US territories only.

You are now leaving ALUNBRIG.com, the official site for ALUNBRIG® (brigatinib) and entering one that is not owned or controlled by Takeda Oncology.

Takeda Oncology makes no representation as to the accuracy of the information contained on sites we do not own or control. Takeda Oncology does not recommend and does not endorse the content on any third-party websites. Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites.

Cancel Continue >
Close

You are now leaving ALUNBRIG.com, the official site for ALUNBRIG® (brigatinib) and entering one that is not owned or controlled by Takeda Oncology.

This link will take you to the corporate ARIAD Pharmaceuticals, Inc. website.

Cancel Continue >
Close

You are now leaving ALUNBRIG.com, the official site for ALUNBRIG® (brigatinib).

This link will take you to another Takeda Oncology website.

Cancel Continue >
Close

The site you are about to enter is intended for US healthcare professionals only.

Please confirm that you are a US healthcare professional.

Yes, I confirm that I am a US healthcare professional Cancel
Close